1 : an ancient region of Mesopotamia lying between the Euphrates delta and the Persian Gulf and the Arabian Desert; settled in 1000 BC and destroyed by the Persians in 539 BC; reached the height of its power under Nebuchadnezzar II
2 : an ancient kingdom in southern Mesopotamia; Babylonia conquered Israel in the 6th century BC and exiled the Jews to Babylon (where Daniel became a counselor to the king)