1 : aroused to impatience or anger; "made an irritated gesture"; "feeling nettled from the constant teasing"; "peeved about being left out"; "felt really pissed at her snootiness"; "riled no end by his lies"; "roiled by the delay"
2 : causing disapproval or protest; "a vulgar and objectionable person"
3 : causing physical discomfort; "bites of black flies are more than irritating; they can be very painful"