1 : unique; "dogs and mice and flies are as unrepeatable as men are"- Theodosius Dobzhansky
2 : the single one of its kind; "a singular example"; "the unique existing example of Donne's handwriting"; "a unique copy of an ancient manuscript"; "certain types of problems have unique solutions"
3 : radically distinctive and without equal; "he is alone in the field of microbiology"; "this theory is altogether alone in its penetration of the problem"; "Bach was unique in his handling of counterpoint"; "craftsmen whose skill is unequaled"; "unparalleled athletic ability"; "a breakdown of law unparalleled in our history"